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Description
Estradiol Vaginal Topical Cream 2.5 mg/mL is indicated for the treatment of vulvar and vaginal atrophy associated with menopause. It replenishes local estrogen levels in vaginal tissues, improving symptoms such as dryness, irritation, burning, and dyspareunia. This formulation is intended for local intravaginal use and is not suitable for systemic hormone replacement.
The cream is applied intravaginally as directed by a healthcare provider, typically in a cyclic or continuous regimen. Treatment is individualized based on symptom severity and patient response. Caution is advised in prolonged use, especially in women with an intact uterus, due to the increased risk of endometrial hyperplasia and cancer.
Common adverse effects include headache, breast tenderness, and nausea. Other symptoms may include localized irritation or discharge. Estradiol may interact with CYP3A4 inhibitors, potentially increasing systemic estrogen exposure. Use should be avoided in individuals with active thromboembolic disorders, undiagnosed vaginal bleeding, or known estrogen-dependent tumors.
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