Additional Information

Description

Dopamine 400 mg/250 mL D5W is a ready-to-use intravenous infusion solution containing dopamine hydrochloride at a concentration of 1600 mcg/mL, diluted in 5% dextrose in water (D5W). It is primarily used as a vasopressor and inotropic agent for the treatment of hemodynamic imbalances in conditions such as shock, heart failure, and low cardiac output states. Dopamine acts by stimulating dopaminergic, beta-adrenergic, and alpha-adrenergic receptors depending on the dose, leading to improved perfusion and cardiac performance.

This formulation is supplied in a sterile, preservative-free infusion bag, designed for continuous administration via intravenous infusion pumps. The inclusion of 5% dextrose in water provides an energy source while ensuring proper dilution of dopamine for controlled delivery. The solution is intended for use in critical care settings under close monitoring by healthcare professionals.

Dopamine’s mechanism of action is dose-dependent. At low doses, it stimulates dopaminergic receptors, improving renal perfusion and diuresis. At moderate doses, it predominantly stimulates beta-adrenergic receptors, enhancing cardiac contractility and output. At higher doses, alpha-adrenergic receptor activation leads to vasoconstriction, improving blood pressure in hypotensive patients.