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Ibrance 75Mg Capsule 21/Ea

  • Manufacturer Name : Pfizer
  • MFG # : 69018721
  • NDC : 69018721
  • Distributor Name : AmeriSource Bergen - SAGEBRUSH
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Additional Information

Product NameIbrance 75Mg Capsule 21/Ea
Active IngredientPalbociclib
Mechanism of ActionSelective inhibition of CDK4/6, leading to cell cycle arrest in the G1 phase and suppression of cancer cell proliferation
Strength75 mg per capsule
Route of administrationOral
Side EffectsNeutropenia, fatigue, nausea, diarrhea, stomatitis, infections, pulmonary toxicity, venous thromboembolism
PrecautionsMonitor blood counts, avoid CYP3A inhibitors/inducers
StorageStore at controlled room temperature, protect from moisture, keep in original container
PackagingBlister pack for protection and accurate dosing
Quantity21 capsules per pack
UsesTreatment of HR-positive, HER2-negative advanced or metastatic breast cancer in combination with endocrine therapy

Description

Ibrance (palbociclib) 75 mg is an oral cyclin-dependent kinase (CDK) 4/6 inhibitor used for the treatment of hormone receptor-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced or metastatic breast cancer. It works by selectively inhibiting CDK4 and CDK6, which regulate cell cycle progression. By blocking these kinases, Ibrance prevents cancer cell proliferation, inducing cell cycle arrest at the G1 phase.

The medication is supplied in 75 mg capsules, with each package containing 21 capsules. It is taken orally once daily for 21 consecutive days, followed by a 7-day treatment-free interval in a 28-day cycle. Ibrance is typically used in combination with an aromatase inhibitor or fulvestrant, depending on the patient's treatment history and menopausal status.

Common adverse effects include neutropenia, fatigue, nausea, stomatitis, diarrhea, and infections. Serious complications such as severe neutropenia, pulmonary toxicity, and venous thromboembolism may occur. Regular blood count monitoring is necessary to detect and manage neutropenia.

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Ibrance 75Mg Capsule 21/Ea is manufactured by Pfizer.
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