Additional Information

Description

Clindamycin Gel 1% (30g) is a topical antibiotic used for the treatment of acne vulgaris. It contains clindamycin phosphate, which is converted into its active form, clindamycin, upon application to the skin. This formulation effectively reduces inflammatory acne lesions by targeting Cutibacterium acnes, the bacteria responsible for acne development.

The mechanism of action involves inhibition of bacterial protein synthesis by binding to the 50S ribosomal subunit, preventing bacterial growth and replication. Clindamycin also has anti-inflammatory properties, reducing redness and swelling associated with acne. The gel formulation allows for better skin absorption and localized antibacterial activity while minimizing systemic absorption and associated side effects.

Common side effects include skin dryness, irritation, redness, itching, and peeling. In rare cases, prolonged use may lead to bacterial resistance or Clostridium difficile-associated diarrhea if significant systemic absorption occurs. It should not be applied to broken or irritated skin and should be used with caution in individuals with a history of gastrointestinal diseases or antibiotic-associated colitis.