Product Details
PHENYTOIN 125MG/5mL USP EA
Manufacturer: TARO PHARMACEUTICAL INDUSTRIES LTD
MFG#: 51672-4069-01
NDC: 51672-4069-01
PID: 417897
Additional Information
| Product Name | Phenytoin 125Mg/5Ml Usp Ea |
| Application | Antiepileptic / Anticonvulsant |
| Generic Drug Name | Phenytoin |
| Mechanism of Action | Blocks voltage-gated sodium channels to stabilize hyperexcitable neuronal membranes and prevent repetitive firing |
| Strength | 125 mg / 5 mL |
| Type | Oral |
| Volume | 237 mL |
| Onset of Action | 30 minutes to 1 hour (oral administration) |
| Half-Life | 22-24 hours (varies with dosage and metabolism) |
| Therapeutic Range | 10-20 mcg/mL (serum concentration) |
| Side Effects | Dizziness, nausea, gum hypertrophy, rash, ataxia |
| Precautions | Regular monitoring of blood levels, liver function, and hematologic parameters |
| Administration Instructions | Shake well before use, measure dose with a calibrated device |
| Pregnancy Category | Category D (use only if benefits outweigh risks) |
| Packaging | Single Bottle |
| Uses | Management of tonic-clonic seizures, partial seizures, and status epilepticus |
Description
Phenytoin 125 mg/5 mL USP is an oral suspension used as an antiepileptic medication for the prevention and treatment of seizures. It is particularly effective in controlling tonic-clonic (grand mal) and partial seizures, including complex partial seizures. By stabilizing neuronal activity, phenytoin helps reduce the frequency and severity of epileptic episodes.
The mechanism of action of phenytoin involves stabilizing hyperexcitable neuronal membranes and reducing repetitive neuronal firing by blocking voltage-dependent sodium channels. This inhibition prevents the excessive firing of neurons associated with seizure activity. Phenytoin does not affect the resting potential of the neurons, ensuring that regular neural communication remains intact.
This medication is typically administered orally and is supplied as a suspension with a concentration of 125 mg per 5 mL. Common side effects include dizziness, nausea, gum hypertrophy, and skin rashes. Phenytoin suspension should be stored at controlled room temperature, shaken well before use, and kept tightly closed to ensure potency and effectiveness.
Frequently Asked Questions (FAQs)
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PHENYTOIN 125MG/5mL USP EA is manufactured by TARO PHARMACEUTICAL INDUSTRIES LTD.
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