Product Details
FOSAPREPITANT 150 MG VIAL
Manufacturer: Hikma Pharmaceuticals Plc
MFG#: 00143-9384-01
NDC: 00143-9384-01
PID: 639450
Additional Information
| Product Name | Fosaprepitant 150 mg Vial |
| Active Ingredient | Fosaprepitant (prodrug of Aprepitant) |
| Drug Class | NK1 Receptor Antagonist |
| Mechanism of Action | Inhibits substance P from binding to NK1 receptors in the brain, reducing chemotherapy-induced nausea and vomiting (CINV) |
| Strength | 150 mg |
| Volume | Vial (for reconstitution) |
| Route of Administration | Intravenous (IV) infusion |
| Side Effects | Fatigue, constipation, elevated liver enzymes, allergic reactions, gastrointestinal issues, liver toxicity |
| Precautions | Monitor liver function, avoid in patients with severe liver disease |
| Storage | Store at controlled room temperature, protect from light, keep in a cool, dry place |
| Packaging | Vial containing 150 mg of fosaprepitant for reconstitution |
| Uses | Prevention of chemotherapy-induced nausea and vomiting (CINV) |
Description
Fosaprepitant 150 mg vial is an intravenous medication used to prevent nausea and vomiting associated with chemotherapy. The active ingredient, fosaprepitant, is a prodrug of aprepitant, a selective neurokinin-1 (NK1) receptor antagonist. By blocking the action of substance P at NK1 receptors in the brain, fosaprepitant effectively reduces the incidence of chemotherapy-induced nausea and vomiting (CINV), which can significantly affect the quality of life of cancer patients.
The drug is administered as an intravenous infusion, typically before chemotherapy begins. Fosaprepitant is often used in combination with other antiemetic medications to enhance the prevention of nausea and vomiting. The recommended dosage is a single infusion of 150 mg, given approximately 30 minutes prior to chemotherapy.
Common side effects include fatigue, constipation, and elevated liver enzymes. Serious adverse effects, though rare, may include severe allergic reactions, liver toxicity, and gastrointestinal issues. Monitoring of liver function is advised during treatment to detect any signs of liver damage or dysfunction.
Frequently Asked Questions (FAQs)
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FOSAPREPITANT 150 MG VIAL is manufactured by Hikma Pharmaceuticals Plc.
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