Product Details
Additional Information
| Product Name | Calquence 100Mg Tab 60/Ea |
| Active Ingredient | Acalabrutinib |
| Mechanism of Action | Irreversibly binds to BTK, inhibiting B-cell receptor signaling to reduce malignant B-cell proliferation |
| Dosage Form | Oral Tablet |
| Strength | 100 mg |
| Administration Instructions | Swallow whole with water, avoid grapefruit and Seville oranges |
| Dosing Frequency | Twice daily (every 12 hours) |
| Common Side Effects | Headache, diarrhea, fatigue, musculoskeletal pain, upper respiratory tract infections |
| Serious Adverse Effects | Atrial fibrillation, major bleeding, infections, cytopenias |
| Monitoring Requirements | Blood counts, signs of bleeding, cardiac arrhythmias, infection risk |
| Storage Conditions | Store at controlled room temperature, protect from moisture |
| Packaging | Bottle containing 60 tablets |
| Indications | Chronic lymphocytic leukemia (CLL), small lymphocytic lymphoma (SLL), mantle cell lymphoma (MCL) |
Description
Calquence (acalabrutinib) 100 mg tablets are a Bruton's tyrosine kinase (BTK) inhibitor indicated for the treatment of certain hematologic malignancies, including chronic lymphocytic leukemia (CLL), small lymphocytic lymphoma (SLL), and mantle cell lymphoma (MCL) in patients who have received at least one prior therapy. By selectively inhibiting BTK, Calquence disrupts B-cell receptor signaling, reducing the proliferation and survival of malignant B cells.
The mechanism of action involves irreversible binding to BTK, which blocks downstream signaling pathways essential for B-cell activation and survival. This inhibition decreases tumor cell growth and improves disease control. Calquence is administered orally and may be used as monotherapy or in combination with other agents, depending on the specific indication.
Common adverse effects include headache, diarrhea, fatigue, musculoskeletal pain, and upper respiratory tract infections. Serious risks include atrial fibrillation, bleeding, infections, and cytopenias. Patients should be monitored for signs of bleeding, cardiac arrhythmias, and immune suppression.
Frequently Asked Questions (FAQs)
The cost of CALQUENCE 100MG TAB 60/EA is $available for registerd members only
CALQUENCE 100MG TAB 60/EA is manufactured by ASTRAZENECA.
You can purchase CALQUENCE 100MG TAB 60/EA on our website at https://supplies.pipelinemedical.com/product/detail/calquence-100mg-tab-60-ea-423239