Product Details

LYNPARZA 150MG TAB 120/EA

Manufacturer: ASTRAZENECA

MFG#: 310067912

NDC: 310067912

PID: 422340

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Additional Information

Product NameLynparza 150 mg Tab 120/Ea
ApplicationPARP Inhibitor for Cancer Treatment
Generic Drug NameOlaparib
Mechanism of ActionInhibits PARP enzymes, preventing DNA repair in cancer cells
Strength150 mg
TypeOral
Volume120 tablets per bottle
Recommended Dosage300 mg (two 150 mg tablets) twice daily
Administration InstructionsSwallow whole, do not crush, chew, or split; can be taken with or without food
Half-life~12 hours
Common Adverse EffectsNausea, anemia, fatigue, vomiting, diarrhea, decreased appetite
Serious RisksMyelodysplastic syndrome, acute myeloid leukemia, pneumonitis, severe bone marrow suppression
Storage ConditionsStore at 20°C to 25°C (68°F to 77°F), protect from moisture and heat
Monitoring RequirementsComplete blood count (CBC), renal function, liver enzymes
IndicationsBRCA-mutated ovarian, breast, pancreatic, and prostate cancers

Description

Lynparza (Olaparib) 150 mg Tablets, 120/Ea is a poly (ADP-ribose) polymerase (PARP) inhibitor used in the treatment of certain cancers associated with BRCA mutations and homologous recombination repair (HRR) deficiencies. It is indicated for patients with advanced ovarian, breast, pancreatic, and prostate cancers who meet specific genetic and clinical criteria. By inhibiting PARP enzymes, it prevents DNA repair in cancer cells, leading to cell death and reduced tumor progression.

Lynparza is administered orally in a recommended dose of 300 mg (two 150 mg tablets) twice daily, totaling 600 mg per day. The tablets should be swallowed whole and not chewed, crushed, or split. Dosing adjustments may be required for patients with renal impairment or those experiencing severe adverse effects. It can be taken with or without food, and consistency in administration timing is recommended for optimal therapeutic effect.

Common adverse effects include nausea, fatigue, anemia, vomiting, diarrhea, and decreased appetite. Serious risks include myelodysplastic syndrome, acute myeloid leukemia, pneumonitis, and severe bone marrow suppression. Regular monitoring of complete blood counts (CBC), renal function, and liver enzymes is necessary during treatment to assess for toxicity.

Frequently Asked Questions (FAQs)

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LYNPARZA 150MG TAB 120/EA is manufactured by ASTRAZENECA.

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